It has been convincingly argued that computer simulation modeling differs from traditional science. If we understand simulation modeling as a new way of doing science, the manner in which scientists learn about the world through models must also be considered differently. This article examines how researchers learn about environmental processes through computer simulation modeling. Suggesting a conceptual framework anchored in a performative philosophical approach, we examine two modeling projects undertaken by research teams in England, both aiming to inform flood risk (...) management. One of the modeling teams operated in the research wing of a consultancy firm, the other were university scientists taking part in an interdisciplinary project experimenting with public engagement. We found that in the first context the use of standardized software was critical to the process of improvisation, the obstacles emerging in the process concerned data and were resolved through exploiting affordances for generating, organizing, and combining scientific information in new ways. In the second context, an environmental competency group, obstacles were related to the computer program and affordances emerged in the combination of experience-based knowledge with the scientists’ skill enabling a reconfiguration of the mathematical structure of the model, allowing the group to learn about local flooding. (shrink)

Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and (...) [18F]-flumazenil PET in a separate group (n = 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAA receptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control. (shrink)

Objective Manic and depressive phases of bipolar disorder (BD) show opposite psychomotor symptoms. Neuronally, these may depend on altered relationships between sensorimotor network (SMN) and subcortical structures. The study aimed to investigate the functional relationships of SMN with substantia nigra (SN) and raphe nuclei (RN) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition. -/- Method In this resting-state functional magnetic resonance imaging (fMRI) study on healthy (n = 67) and BD (...) patients (n = 100), (1) functional connectivity (FC) between thalamus and SMN was calculated and correlated with FC from SN or RN to basal ganglia (BG)/thalamus in healthy; (2) using an a-priori-driven approach, thalamus-SMN FC, SN-BG/thalamus FC, and RN-BG/thalamus FC were compared between healthy and BD, focusing on manic (n = 34) and inhibited depressed (n = 21) patients. -/- Results (1) In healthy, the thalamus-SMN FC showed a quadratic correlation with SN-BG/thalamus FC and a linear negative correlation with RN-BG/thalamus FC. Accordingly, the SN-related FC appears to enable the thalamus-SMN coupling, while the RN-related FC affects it favoring anti-correlation. (2) In BD, mania showed an increase in thalamus-SMN FC toward positive values (ie, thalamus-SMN abnormal coupling) paralleled by reduction of RN-BG/thalamus FC. By contrast, inhibited depression showed a decrease in thalamus-SMN FC toward around-zero values (ie, thalamus-SMN disconnection) paralleled by reduction of SN-BG/thalamus FC (and RN-BG/thalamus FC). The results were replicated in independent HC and BD datasets. -/- Conclusions These findings suggest an abnormal relationship of SMN with neurotransmitters-related areas via subcortical-cortical loops in mania and inhibited depression, finally resulting in psychomotor alterations. (shrink)

The neurotransmitters GABA and glutamate have been suggested to play a role in Major Depressive Disorder (MDD) through an imbalance between cortical inhibition and excitation. This effect has been highlighted in higher brain areas, such as the prefrontal cortex, but has also been posited in basic sensory cortices. Based on this, magnetic resonance spectroscopy (MRS) was used to investigate potential changes to GABA+ and glutamate+glutamine (Glx) concentrations within the occipital cortex in MDD patients (n = 25) and healthy controls (n (...) = 25). No difference in occipital GABA+ or Glx concentrations, nor in the GABA+/Glx ratio, was found between groups. An analysis of an extended MDD patient and unmatched control dataset (n = 90) found no correlation between metabolite concentrations and depressive symptoms. These results were integrated with prior studies through metabolite-specific meta-analyses, revealing no difference in occipital GABA and Glx concentrations between patients and controls. An effect of publication year on GABA group differences was found, suggesting that previously reported results may have been artifacts of measurement accuracy. Taken together, our results suggest that, contrary to some prior reports, MRS measurements of occipital GABA and Glx do not differ between MDD patients and controls. (shrink)

Background: Rumination, a tendency to focus on negative self-related thoughts, is a central symptom of depression. Studying the self-related aspect of such symptoms is challenging because of the need to distinguish self effects from the emotional content of task stimuli. This study employed an emotionally neutral self-related paradigm to investigate possible altered self-processing in depression and its link to rumination. Methods: People with major depressive disorder (n = 25) and controls (n = 25) underwent task-based electro-encephalogram recording. We studied late (...) event-related potentials, along with low-frequency oscillatory power. We compared electroencephalogram metrics between groups and correlated them with depressive symptoms and reported rumination. Results: Participants with major depressive disorder displayed a difference in late positive potentials across frontocentral electrodes between self-related and non-self-related conditions. We found no such difference in controls. The magnitude of this difference was positively correlated with depressive symptoms and reported rumination. Participants with major depressive disorder also had elevated theta oscillation power at central electrodes in self-related conditions, a finding that we did not see in controls. Limitations: Patients with major depressive disorder were medicated at the time of the study. The group studied was primarily female, so the observed effects may have been sex-specific. Conclusion: Rumination appears to be linked to altered self-related processing in depression, independent of stimuli-related emotional confounds. This connection between self-related processing and depression may point to a self disorder as a core component of depression. (shrink)

Imprint covered by label which reads : Barnes & Noble Books, Totowa, N.J. Includes bibliographical references and index.

In lieu of an abstract, here is a brief excerpt of the content:GOD'S KNOWLEDGE OF FUTURE CONTINGENT SINGULARS: A REPLY THEODORE J. KoNDOLEON Villanova University Villanova, Pennsylvania I N A RECENT article in The Thomist William Lane Craig has discussed certain aspects of Saint Thomas's teaching on God's knowledge of creatures. While for Craig Saint Thomas's concept of God's knowledge of vision (scientia visionis) is not fatalistic, his concept of God's knowledge of approbation (i.e., God's causal knowledge) is.1 Craig (...) believes that this latter type of divine knowledge implies fatalism since, on his reading, its causality determines everything that takes place in this universe. In developing his argument Craig makes a number of statements (and arguments) which are not only at variance with Saint Thomas's expressed thought but which, I believe, are also clearly mistaken. Some of his errors are of a trivial sort and may in part be due to the fact that he occasionally misspeaks himself. One can single out in this regard his statement, on page 78, that "God's knowledge does not necessitate an effect because an effect may be impeded by its secondary cause," and also his observation, on page 79, that "God's knowledge is the cause of everything God knows." 2 However, there are a number of more 1 See William Lane Craig, "Aquinas on God's Knowledge of Future Contingents," The Thomist, 54 (January 1990): 33-79. For his discussion of Thomas's teaching on God's knowledge of vision see particularly pp. 32-67; on Aquinas's teaching on God's causal knowledge, pp. 68-79. 2 Contrary to Craig's way of stating this, Aquinas never speaks about an effect being impeded by its secondary cause. Rather, a contingent cause may be impeded from producing its effect by the intervention of another secondary cause. Examples would be frost preventing the production or development of the fruit of certain plants, or a drug preventing the development of a normal embryo. For Aquinas's discussion of a contingent cause see De veritate, q. 2, a. 12, c. and also Summa contra Gentiles, Book I, chap. 67. Concerning 117 118 THEODORE J. KONDOLEON serious errors to be found in his discussion of God's knowledge of creatures, and it is to these that I would like to address this reply. I. In discussing the topic of God's knowledge of future contingent singulars, Craig considers Saint Thomas's explanation as to how it is possible for God to know what is future and contingent (i.e., something which, from the standpoint of its proximate cause, can either come to be or not come to be). As generally known, his explanation points out that while what is future and contingent with respect to its proximate cause(s)-and thus also from our vantage point-is something indeterminate in being and therefore in truth and knowability, as falling within the scope of God's eternal knowledge it is something already present (and thus determined to one of two opposites) and, consequently, can be known with certitude.3 In this Thomistic view, then, there is no past or future in God's knowledge of created things; everything is known at once and as present. At this point in his discussion, when he has yet to consider Saint Thomas's position that God's knowledge of things is also a causal knowledge (i.e., a knowledge which involves God's will as First Cause of His creatures and their actions), Craig claims that Saint Thomas employs the Boethian notion of God's eternity, and thus of His timeless knowledge, in order to " defuse the threat of fatalism." ' He holds this view because, he argues, otherwise, i.e., if God's knowledge were something past with respect to a future contingent singular (so that God could be said to " foreknow " it), that future would be something which would necessarily come to be-either that or else God could be mistaken-and therefore not truly Craig's second observation, it is not true to say, even of God's causal knowledge, that God's knowledge is the cause of everything God knows since God knows many things He will never cause... (shrink)

According to familiar accounts, Rousseau held that humans are actuated by two distinct kinds of self love: amour de soi, a benign concern for one's self-preservation and well-being; and amour-propre, a malign concern to stand above other people, delighting in their despite. I argue that although amour-propre can (and often does) assume this malign form, this is not intrinsic to its character. The first and best rank among men that amour-propre directs us to claim for ourselves is that of occupying (...) 'man's estate'. This does not require, indeed it precludes, subjection of others. Amour-propre does not need suppression or circumscription if we are to live good lives; it rather requires direction to its proper end, not a delusive one. (shrink)

We discuss three varieties of affective dynamics ( affective instability, emotional inertia, and emotional differentiation). In each case, we suggest how these affective dynamics should be operationalized and measured in daily life using time-intensive methods, like ecological momentary assessment or ambulatory assessment, and recommend time-sensitive analyses that take into account not only the variability but also the temporal dependency of reports. Studies that explore how these affective dynamics are associated with psychological disorders and symptoms are reviewed, and we emphasize that (...) these affective processes are within a nexus of other components of emotion regulation. (shrink)

Life, but not as we know it -- Still life in nearly present time -- Driving and the city -- Movement-space -- Afterwords -- From born to made -- Spatialities of feeling -- But malice aforethought -- Turbulent passions.

How do we refer to people in everyday conversation? No matter the language or culture, we must choose from a range of options: full name ('Robert Smith'), reduced name ('Bob'), description ('tall guy'), kin term ('my son') etc. Our choices reflect how we know that person in context, and allow us to take a particular perspective on them. This book brings together a team of leading linguists, sociologists and anthropologists to show that there is more to person reference than meets (...) the eye. Drawing on video-recorded, everyday interactions in nine languages, it examines the fascinating ways in which we exploit person reference for social and cultural purposes, and reveals the underlying principles of person reference across cultures from the Americas to Asia to the South Pacific. Combining rich ethnographic detail with cross-linguistic generalizations, it will be welcomed by researchers and graduate students interested in the relationship between language and culture. (shrink)

Liberal critics of plato's republic criticise him for ignoring the moral autonomy of persons, their right to form and to express their own moral ideas. It is argued that this criticism is superficial. Neither plato, nor his liberal critics, wish all moral views to be held and acted on; they both wish to set limits to what is acceptable. The true source of disagreement is over the scope of reason in human affairs; plato understands that narrowly; his liberal critics in (...) a broad, permissive, way. (shrink)

This part of the philosophy of psychology I refer to as 'moral psychology'; and, therefore, this book is offered as a contribution to moral psychology. ...